Juliette Lewis was born in Los Angeles, California to Geoffrey Lewis, an actor, and Glenis Duggan Batley, a graphic designer. She has four siblings - brothers Lightfield and Peter, and sisters Deirdre and Brandy.
She appeared in The Wonder Years as Wayne's girlfriend in Episodes 24, 34 and 36. Lewis first garnered international attention and acclaim in 1991 with her turn as Danielle Bowden in Martin Scorsese's remake of Cape Fear, for which she was nominated for an Academy Award for Best Supporting Actress in 1991. Over the next few years, she won further critical support in Peter Medak's Romeo Is Bleeding, and opposite Brad Pitt in Kalifornia. In 1993 she acted alongside Leonardo DiCaprio and Johnny Depp in the drama film What's Eating Gilbert Grape. She played Mallory Knox in Oliver Stone's Natural Born Killers. She played a rock singer in the film Strange Days, doing her own singing on covers of two songs written by PJ Harvey, giving fans an early look at her musical prowess.
She received an Emmy nomination for her performance in Hysterical Blindness in 2003. She also appeared in the HIM music video for "Buried Alive By Love" in 2003.
Lewis appeared in Rockstar Games' Grand Theft Auto IV, providing the voice of "Juliette", the host of fictional radio station "Radio Broker". She starred in the video for the Melissa Etheridge song "Come To My Window", and has also appeared in a GAP commercial which she was dancing with Daft Punk to the tune of the song "Digital Love".